Ig gamma-1 chain C region
Rituximab
CAS: 174722-31-7
Molecular Formula: C6416H9874N1688O1987S44
Ig gamma-1 chain C region - Names and Identifiers
Ig gamma-1 chain C region - Physico-chemical Properties
| Molecular Formula | C6416H9874N1688O1987S44 |
| Storage Condition | -20℃，避光 |
| In vitro study | The potency of Rituximab depends primarily on its complement-dependent toxicity (CDC), complement-dependent cytotoxicity (CDCC), antibody-dependent cytotoxicity (ADCC), and apoptosis-inducing effects. Rituximab induces the death of malignant B cells in vitro. The potency of the action varies with different target cells. In vitro, the cellular changes induced by Rituximab are: p38 MAPK, NF-κB, ERK1/2, inhibition of AKT anti-apoptotic, survival signaling pathways. Rituximab is highly effective in mediating complement-dependent toxicity (CMC) of different B cell lines and malignant B cells. The CD20 binding capacity of Rituximab was concentration-dependent. |
| In vivo study | Some in vivo tumor models have demonstrated that the anti-tumor activity of rituximab depends (at least in part) on complement. Rituximab can deplete B cells for several months and thus can be an effective regimen for the treatment of B cell-mediated autoimmune diseases. Rituximab is widely used in the treatment of hematological tumors and is currently in the development of drugs for the treatment of several autoimmune diseases. |
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Product Name: Rituximab Request for quotation
CAS: 174722-31-7
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CAS: 174722-31-7
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
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Product Name: Rituximab Request for quotation
CAS: 174722-31-7
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
CAS: 174722-31-7
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
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